SEVERE METABOLIC ACIDOSIS FOLLOWING HYPOTENSION INDUCED WITH SODIUM NITROPRUSSIDE
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چکیده
منابع مشابه
Metabolic effects of induced hypotension with trimetaphan and sodium nitroprusside.
In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. Nitroprusside (15 patients) was associated with a s...
متن کاملCyanide toxicity following nitroprusside induced hypotension.
Several recently reported deaths following the use of sodium nitroprusside have been attributed to the accumulation of the nitroprusside metabolite, cyanide. In this study, brief nitroprusside infusions (mean = 36 minutes) were administered in currently recommended doses during intracranial surgery. The peak blood cyanide following the infusions was 65.2 +/- 17.5 microgram per cent (mean +/- SE...
متن کاملEffect of sodium nitroprusside-induced hypotension on pulmonary deadspace.
Deliberate hypotension with nitroprusside produced a 40% reduction in mean arterial pressure, but it did not cause any change in the pulmonary deadspace to tidal volume ratio ( Vb/ Vr). This was achieved by adequate hydration both before and during hypotension, as indicated by constant filling pressures. Thus we have shown that deliberate hypotension per se does not increase Vb/ VT, and that va...
متن کاملSodium nitroprusside is not associated with metabolic acidosis during intraoperative infusion in children
BACKGROUND Sodium nitroprusside (SNP) is a potent vasodilator that has been used to induce deliberate hypotension in children during surgery involving significant blood loss, including craniofacial and spinal fusion procedures. SNP metabolism liberates cyanide, which may cause interference with cellular energy metabolism, leading to metabolic acidosis and central nervous system injury. We perfo...
متن کاملMETABOLIC ACIDOSIS AND SEVERE HYPOTENSION: INFLUENCE ON SURVIVAL TIME AND SHOCK PERIOD DURING HEMORRHAGE IN THE CAT
Metabolic acidosis and severe hypotension are the main causes of irreversibility during hemorrhagic shock. The influence of these two factors on durations of shock period and survival time were studied in four groups of anesthetized cats. In group I the animals were made hypotensive by reducing mean arterial blood pressure (Pa) to 45 mmHg with concurrent metabolic acidosis. [n group II the ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1974
ISSN: 0007-0912
DOI: 10.1093/bja/46.10.795